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Being full of Shit is one thing, but being full of someone elses Shit? Oh man!

In 1928, while in his lab, the biologist discovered that an active ingredient in the mold Penicillium notatum was an infection-fighting agent that could kill colonies of the bacterium Staphylococcus aureus.

The discovery of penicillin lead to the production of antibiotics, drugs that could kill disease-causing bacteria. Bye bye, syphilis? Bye bye, gangrene? Bye bye, tuberculosis? Well…almost. Doctors started prescribing them and then over-prescribing them. And we started using them and abusing them.

However, this spawned antibiotic resistance and suberbugs, a problem as lethal as the infection itself. Now, experts warn that we are at the end of the antibiotic era.

“It’s already happening,” University of California, Los Angeles professor Brad Spellberg told Newsweek — to the tune of roughly 100,000 deaths a year from antibiotic-resistant infections in the United States alone. “But it’s going to become much more common.”

For instance, Methicillin-resistant Staphylococcus aureus, or MRSA is a superbug. When it enters the blood stream and attacks the body, the infection can grow so large only surgery can get rid of the drug-resistant bug.

Right now, our best line of defense against MRSA is antibiotics. Sometimes, as a last line of defense, doctors prescribe vancomycin and linezolid. Although even those drugs aren’t guaranteed to work.

Suberbugs like MRSA are becoming a huge problem in hospitals, but scientists have been working to combat the spread of the potentially deadly bug.

Here are five technologies that stand a chance against superbugs:

1. Fecal transplants: Restoring the bacterial flora of the colon to the native state through a donor can literally stop a potentially deadly Clostridium difficile infection from taking over. Anyone’s poo will suffice, as long as it is screened for infectious diseases. But your siblings may make the best donors.